Fatigue or tiredness is one of the most common symptoms in clinical medicine. Fatigue refers to an subjective human experience of physical and mental weariness, sluggishness, and exhaustion. It is a prominent manifestation of a number of systemic, neurological, and psychiatric syndromes.
1. Psychiatric Disease
Fatigue is a common symptom in many major psychiatric syndromes, including depression, anxiety. Psychiatric symptoms are reported in more than three-quarters of patients with unexplained chronic fatigue.
2. Neurological Disease
Fatiquness of muscle power is a cardinal manifestation of some neuro muscular disorders such as myasthenia gravis. Fatigue is one of the most common and bothersome symptoms reported in multiple sclerosis affecting nearly 90% of patients; fatigue in MS can persist between MS attacks. Tiredness is also identified as a troublesome feature of many other neurodegenerative disease, including Parkinson’s disease, central dysautonomia. Fatigue is also a frequent result of traumatic brain injury, often occurring in association with depression and sleep disorders.
3. Sleep Disorders
Obstructive sleep apnea is an important cause of excessive daytime sleepiness. This occurs particularly in those with prominent snoring, obesity, or other predictors of obstructive sleep apnea.
4. Endocrine Disorders
Fatigue can be a heralding symptom of hypothyroidism, associated with hair loss, dry skin, cold intolerance, constipation, and weight gain. Fatigue in association with heat intolerance, sweating, and palpitations is typical of hyperthyroidism. Adrenal insufficiency, hypercalcemia , hypoglycemia, Cushing’s disease, hypoaldosteronism, and hypogonadism can also manifest with unexplained fatigue.
Obesity is associated with fatigue and sleepiness independent of the presence of obstructive sleep apnea. A number of other factors common in obese patients are likely contributors as well, including depression, physical inactivity, and diabetes.
6. Chronic Fatigue Syndrome
Chronic fatigue syndrome is a disorder characterized by intense fatigue that does not improve with rest and which may be made worse by physical or mental exertion. It is unknown what causes this condition.
Some other conditions that can make you tired are:
- Vitamin D deficency
- Many medications like opiates, antispasticity agents, antiseizure agents, and beta blockers
- Liver and Kidney Disease
So, in whatever condition, body has to work more than its capacity or anything wrong in the body; you may feel tired.
The first priority of treatment is to address the underlying disorder or disorders that account for fatigue, because treatment depends upon the cause only.